PhD, Animal Biotechnology & Biomedical Sciences
University of Massachusetts Amherst (2015)

MS, Food Science
University of Massachusetts Amherst (2009)

MS, Animal Science
Korea University (2004)

BS, Animal Science
Korea University (2002)

Academic Positions

Instructor, Stanford University School of Medicine (2021–2026)

Postdoctoral Fellow, Stanford University (2015–2021)

Major Awards

Minister’s Award, Ministry of Science and ICT (MSIT), Republic of Korea (2025)

Scholarship Award, Santa Cruz Developmental Biology Meeting, Santa Cruz, CA (2018)

Best Talk Award, 2nd Annual CVI Postdoctoral Conference, Stanford, CA (2017)

Outstanding Student Award, New England Bioscience Society, Boston, MA (2015)

Poster Award, 2nd place, Activated Egg Symposium, Boston, MA (2013)

Travel Grant Award, Annual Meeting of Society of Developmental Biology, Montreal, Canada (2012)

Poster award, 1st place, Northeast Regional Meeting of the Society for Developmental Biology, Woods Hole, MA (2010)

Poster award, 1st place, Annual Meeting of Animal Science Society in Korea (2004)

Travel Grant Award, Visiting Japan as a student representative for Korea University (2002)
​​​​​​​
Academic scholarship award, PURINA Korea (2001)

Selected Publications

Cho S*, Rhee S*, Madl CM, Caudal A, Kojic A, Thomas D, Kim H, Shin H, Mahajan A, Jahng JW,
Thai PN, Wang X, Paik DT, Wang M, Mullen M, Baker NM, Leitz J, Mukherjee S, Zhang H, Blau
HM, Wu JC#
Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis.
Nature 2025 Apr 30 [IF = 48.5]

2. Cho HH*, Rhee S*, Cho DI, Jun JH, Heo H, Cho SH, Kim D, Wang M, Kang BG, Yoo SJ, Cho M,
Lim S, Cho JY, Jeong IS, Kim YS#, Ahn Y#
IKKε-deficient macrophages impede cardiac repair after myocardial infarction by enhancing the
macrophage–myofibroblast transition.
Experimental & Molecular Medicine 2024 Sep 12 [IF = 12.9]

3. Rhee S*# & Wu JC*#
Vein to artery: the first arteriogenesis in the mammalian embryo.
Cell Research 2022 Feb 10 [IF = 25.9]

4. Rhee S*, Paik DT*, Yang JY, Nagelberg D, Williams I, Tian L, Roth R, Chandy M, Ban J, Belbachir
N, Kim S, Zhang H, Phansalkar R, Wong KM, King DA, Valdez C, Winn VD, Morrison AJ, Wu JC#,
Red-Horse K#
Endocardial/endothelial angiocrines regulate cardiomyocyte development and maturation and
induce features of ventricular non-compaction.
European Heart Journal 2021 July 19 [IF = 35.6]
* Accompanied Editorial: Wagner JU, Dimmeler S. European Heart Journal (2021) 4277-4279.

5. Rhee S*, Chung JI*, King DA, D&aposamato G, Paik DT, Duan A, Chang A, Nagelberg D, Sharma B,
Jeong Y, Diehn M, Wu JC, Morrison AJ#, Red-Horse K#
Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease.
Nature Communications 2018 Jan 25 [IF = 15.7]

6. Rhee S*, Guerrero-Zayas MI, Wallingford MC, Ortiz-Pineda P, Mager J, Tremblay KD#
Visceral endoderm expression of Yin-Yang1 (YY1) is required for VEGFA maintenance and yolk
sac development.
PLoS One 2013 Mar 15 [IF = 2.6]

Corresponding Author
7. Kim H*, Choi S*, Heo H, Cho SH, Lee Y, Kim D, Jung KO, Rhee S#
Applications of Single-Cell Omics Technologies for Induced Pluripotent Stem Cell-Based
Cardiovascular Research.
International Journal of Stem Cells 2024 Aug 12 [IF = 2.4]
*Selected as a Cover Image

8. Lee JE*, Chung Y, Rhee S#, Kim TH#
Untold story of human cervical cancers – HPV-negative cervical cancer.
BMB Reports 2022 July 20 [IF = 3.3]

9. Roth R*, Kim S, Kim J, Rhee S#
Single-cell and Spatial transcriptomics approaches of cardiovascular development and disease.
BMB Reports 2020 Aug 15 [IF = 3.3]
*Selected as a Cover Image

Contributing Author (Selected)
10. Su T*, Stanley G*, Sinha R*, d&aposAmato G, Das S, Rhee S, Chang AH, Poduri A, Raftrey B, Dinh TT,
Roper WA, Li G, Quinn KE, Caron KM, Wu S, Miquerol L, Butcher EC, Weissman I, Quake S, Red-
Horse K#
Single-cell analysis of early progenitor cells that build coronary arteries.
Nature 2018 July 3 [IF = 48.5]

11. Wei TT*, Chandy M*, Nishiga M*, Zhang A, Kumar KK, Thomas D, Manhas A, Rhee S, Justesen
JM, Chen IY, Wo HT, Khanamiri S, Yang JY, Seidl FJ, Burns NZ, Liu C, Sayed N, Shie JJ, Yeh
CF, Yang KC, Lau E, Lynch KL, Rivas M, Kobilka BK, Wu JC#
Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation.
Cell 2022 May 12 [IF = 42.5]

12. Das S*, Goldstone AB*, Wang H, Farry J, D&aposAmato G, Paulsen MJ, Eskandari A, Hironaka CE,
Phansalkar R, Sharma B, Rhee S, Shamskhou EA, Agalliu D, de Jesus Perez V, Woo YJ, Red-
Horse K#
A unique collateral artery development program promotes neonatal heart regeneration.
Cell 2019 Feb 21 [IF = 42.5]

13. Binkley MS*, Jeon YJ*, Nesselbush M, Moding EJ, Nabet BY, Almanza D, Kunder C, Stehr H, Yoo
CH, Rhee S, Xiang M, Chabon JJ, Hamilton E, Kurtz DM, Gojenola L, Owen SG, Ko RB, Shin JH,
Maxim PG, Lui NS, Backhus LM, Berry MF, Shrager JB, Ramchandran K, Padda SK, Das M, Neal
JW, Wakelee HA, Alizadeh AA, Loo BW Jr, Diehn M#
KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by
Glutaminase Inhibition.
Cancer Discovery 2020 Dec 1 [IF = 33.3]

14. Paik DT*, Tian L*, Williams IM*, Rhee S, Zhang H, Liu C, Mishra R, Wu SM, Red-Horse K, Wu JC#
Single-Cell RNA Sequencing Unveils Unique Transcriptomic Signatures of Organ-Specific
Endothelial Cells.
Circulation 2020 Sep 15 [IF = 38.6]

15. Jung KO*, Kim TJ, Yu JH, Rhee S, Zhao W, Ha B, Red-Horse K, Gambhir SS, Pratx G#
Whole-body tracking of single cells via positron emission tomography.
Nature Biomedical Engineering 2020 Jun 15 [IF = 26.6]

16. Paik DT*, Tian L*, Lee J, Sayed N, Chen IY, Rhee S, Rhee JW, Kim Y, Wirka RC, Buikema JW,
Wu SM, Red-Horse K, Quertermous T, Wu JC#
Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells.
Circulation Research 2018 July 9 [IF = 20.3]

17. Buikema JW*, Lee S*, Goodyer WR, Maas RG, Chirikian O, Li G, Miao Y, Paige SL, Lee D, Wu H,
Paik DT, Rhee S, Tian L, Galdos FX, Puluca N, Beyersdorf B, Hu J, Beck A, Venkamatran S,
Swami S, Wijnker P, Schuldt M, Dorsch LM, van Mil A, Red-Horse K, Wu JY, Geisen C, Hesse M,
Serpooshan V, Jovinge S, Fleischmann BK, Doevendans PA, van der Velden J, Garcia KC, Wu
JC, Sluijter JPG, Wu SM#
Wnt activation and reduced cell-cell contact synergistically induce massive expansion of functional
human iPSC-derived cardiomyocytes.
Cell Stem Cell 2020 July 04 [IF = 20.4]

18. Dinh TT*, Xiang M*, Rajaraman A*, Wang Y, Salazar N, Zhu Y, Roper W, Rhee S, Brulois K,
O&aposHara E, Kiefel H, Dinh TM, Bi Y, Gonzalez D, Bao EP, Red-Horse K, Balogh P, G.bris F,
Gaszner B, Berta G, Pan J#, Butcher EC#
An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression.
Nature Communications 2022 Nov 30 [IF = 15.7]

19. Jeon YJ*, Kim T*, Park D, Nuovo GJ, Rhee S, Joshi P, Lee BK, Jeong J, Suh SS, Grotzke JE, Kim SH, Song J, Sim H, Kim Y, Peng Y, Jeong Y, Garofalo M, Zanesi N, Kim J, Liang G, Nakano I,
Cresswell P, Nana-Sinkam P, Cui R#, Croce CM#
miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of
NSCLC.
Nature Communications 2018 Nov 30 [IF = 15.7]

20. Lek W*, Tan W, Seow WQ, Zhang A, Rhee S, Wong WH, Greenleaf WJ, Wu JC#
Current and future perspectives of single-cell multi-omics technologies in cardiovascular research.
Nature Cardiovascular Research 2023 Feb 10 [IF = 10.8]

21. Kim J*, Rothov. MM*, Madan E*, Rhee S, Weng G, Palma AM, Liao L, David E, Amit I, Hajkarim
MC, Vudatha V, Guti.rrez-Garc.a A, Moreno E, Winn R, Trevino J, Fisher PB, Brickman JM,
Gogna R#, Won KJ#
Neighbor-specific gene expression revealed from physically interacting cells during mouse
embryonic development.
PNAS 2023 Jan 3 [IF = 9.1]

Contributing Author (Others)
22. Kim K*, Jung KO*#, Oh S, Kim YH, Lee SY, Hong S, Cho SH, Kim H, Rhee S, Cheon GJ, Kang
KW, Chung JK, Youn H#
Radiation-induced exosomal miR-21 enhances tumor proliferation and invasiveness in breast
cancer: implications for poor prognosis in radiotherapy patients.
Experimental Hematology & Oncology 2024 Dec 18 [IF = 13.5]

23. Hong S*, Lee DS, Bae GW, Jeon J, Kim HK, Rhee S, Jung KO#
In Vivo Stem Cell Imaging Principles and Applications.
International Journal of Stem Cells 2023 Aug 30 [IF = 2.4]

24. Hong S*, Rhee S, Jung KO#
In vivo molecular and single cell imaging
BMB Reports 2022 July 01 [IF = 3.3]

25. Jung JH*, Ikeda G, Tada Y, von Bornst.dt D, Santoso MR, Wahlquist C, Rhee S, Jeon YJ, Yu AC,
O&aposbrien CG, Red-Horse K, Appel EA, Mercola M, Woo J, Yang PC#
miR-106a–363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3
pathway in ischemic heart injury.
Basic Research in Cardiology 2021 Mar 18 [IF = 8.0]

26. Jung KO*, Kim YH, Chung SJ, Lee CH, Rhee S, Pratx G, Chung JK, Youn H#
Identification of Lymphatic and Hematogenous Routes of Rapidly Labeled Radioactive and
Fluorescent Exosomes through Highly Sensitive Multimodal Imaging.
International Journal of Molecular Sciences 2020 Oct 22 [IF = 4.9]

27. Kim KM*, Zamaleeva AI, Lee YW, Ahmed MR, Kim E, Lee HR, Pothineni VR, Tao J, Rhee S,
Jayakumar M, Inayathullah M, Sivanesan S, Red-Horse K, Palmer TD, Park J, Madison DV, Lee
HY#, Rajadas J#
Characterization of brain dysfunction induced by bacterial lipopeptides that alter neuronal activity
and network in rodent brains.
Journal of Neuroscience 2018 Dec 12 [IF = 4.4]
*Selected as a Cover Image

28. El Sebae GK*, Malatos JM, Cone MKE, Rhee S, Angelo JR, Mager J, Tremblay KD#
Single-cell murine genetic fate mapping reveals bipotential hepatoblasts and novel multi-organ
endoderm progenitors.
Development 2018 Sep 19 [IF = 3.6]

29. Kessler D*, Sang H*, Bousquet A, Hulvey JP, Garcia D, Rhee S, Hoshino Y, Yamada T, Jung G#
Nucleic adaptability of heterokaryons to fungicides in a multinucleate fungus, Sclerotinia
homoeocarpa.
Fungal Genetics and Biology 2018 Jan 11 [IF = 2.3]

30. Poduri A*, Raftrey B, Chang AH, Rhee S, Van M, Red-Horse K#
Endothelial cells respond to the direction of mechanical stimuli through SMAD signaling to regulate
coronary artery size.
Development 2017 July 22 [IF = 3.6]

31. Beketaev I*, Zhang Y*, Weng KC, Rhee S, Yu W, Liu Y, Mager J, Wang J#
cis-regulatory control of Mesp1 expression by YY1 and SP1 during mouse embryogenesis.
Developmental Dynamics 2015 Sep 18 [IF = 1.5]

32. Wang J*, Rhee S, Palaria A, Tremblay KD#
FGF signaling is required for anterior but not posterior specification of the murine liver bud.
Developmental Dynamics 2014 Oct 9 [IF = 1.5]

33. Hur S*, Whitcomb F, Rhee S, Park Y, Good DJ, Park Y#
Effects of trans-10, cis-12 conjugated linoleic acid on body composition in genetically obese mice.
Journal of Medicinal Food 2008 Jun 3 [IF = 2.0]

34. Park GY*, Mun S, Park Y, Rhee S, Decker EA, Weiss J, McClements DJ, Park Y#
Influence of encapsulation of emulsified lipids with

Human Developmental Biology